作者:2022-09-22浏览次数:795

陈贵泉-欧洲杯下单平台

博士研究生导师简介

姓名

陈贵泉

研究方向:

分子神经生物学

欧洲杯买球app的联系方式

chenguiquan@nju.edu.cn

学术兼职:


中国细胞生物学会委员;

中国神经生物学会委员。

个人简介

陈贵泉于2005年在英国爱丁堡大学获得神经科学博士学位。陈贵泉实验室长期从事神经系统相关疾病的机理研究。实验室主要利用分子生物学、细胞神经生物学和遗传学等手段研究小头畸形及阿尔茨海默病(ad)的致病机制。研究方向包括以下三个方面:(1)神经干细胞和胶质前体细胞命运决定的分子机制;(2)神经退行死亡的分子机制;(3ad药物的筛选及作用机制的研究。

代表性论文[*通讯作者]

  1. xiay, zhang y, xu m, zou x, gao j*, ji m*, cheng*. presenilinenhancer2 is crucial for the transition of apical progenitorsinto neurons but into not basal progenitors in the developinghippocampus. development2022 (149):dev.200272.

  2. tengx, hu p, chen y, zang y, ye x, ou j, cheng*,shi ys*. anovel lgi1 mutation causes white matter abnormalities and impairsmotor coordination in mice. fasebj. 2022(36):e22212.

  3. wangh, liu m, ye z, zhou c, bi h, wang l, zhang c, fu h, shen y, yangj, hu y*, chen g*.akt regulates sox10 expression to control oligodendrocytedifferentiation via phosphorylating foxo1. j.neurosci. 2021(41): 8163-8180.

  4. houj, bi h, ye z, huang w, zou g, zou x, shi y, shen y, ma q,kirchhoff f, hu y*, cheng*. pen-2negatively regulates the differentiation of oligodendrocyteprecursor cells into astrocytes in the central nervous system. j.neurosci. 2021(41):4976-4990.

  5. wanghliumzougwangl, duan whex, ji mzoux, hu y*,yang j*cheng*.deletion of pdk1 inoligodendrocyte lineage cells causes white matter abnormality andmyelinationdefect in the central nervous system.neurobiol. dis.2021 (148): 105212.

  6. bihzhouczhangycaixjimyangjcheng*,hu y*.neuron-specific deletion of presenilin enhancer2 causesprogressive astrogliosis and agerelated neurodegeneration in thecortex independent of the notch signaling. cnsneurosci. ther.2021 (27):174-185.

  7. wuj, shao c, ye x, di x, li d, zhao h, zhang b*, cheng*, liu h-k*, qiany* (2021) in vivo brain imaging of amyloid-aggregatesin alzheimer's disease with a near-infrared fluorescent probe.acs sensors2021 (6):863-870.

  8. wangq, gong l, mao s, yao c, liu m, wang y, yang j, yu b, cheng*, gu x*.klf2-vav1-rac1 axis promotes axon regeneration after peripheralnerve injury. exp.neurol.2021 (343):113788.

  9. shaoc, yuan j, liu y, wang x, gu j, cheng, zhang b, liu h,zhao j*,zhu h* andqian y*.epilepticbrain fluorescent imaging reveals apigenin can relieve themyeloperoxidase-mediated oxidative stress and inhibitferroptosis.pnas2020 (117):10155-10164.

  10. huangc, liu t, wang q, hou w, zhou c, song z, shi ys, gao x, cheng*,yin z*and hu y*.loss of pp2a disrupts the retention of radial glial progenitorsin the telencephalic niche to impair the generation of late-bornneurons during cortical development (coverstory). cereb.cortex2020(30):4183-4196.

  11. ma x, wang y, hua j, xu c,yang t, yuan j, cheng*,guo z*and wang x*.aβ-sheet-targeted theranostic agent for diagnosing andpreventing aggregation of pathogenic peptides in alzheimer’sdisease (coverstory). sci.china chem.2020 (63):73-82.

  12. chengs, liu t, hu y, xia y, hou j, huang c, zou x, shi y, zheng y, luj* and cheng*.conditional inactivation ofpen-2 in thedeveloping neocortex leads to rapid switch of apical progenitorsto basal progenitors. j.neurosci. 2019(39):2195-2207.

承担科研项目[项目负责人]

1. 国家自然科学基金重大研究计划培育项目一项;

2. 国家自然科学基金面上项目一项。



获奖情况



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