王勇博士
教授
电话：83686495邮箱：yongwang@nju.edu.cn 地址：南京大学医学院科研中心（原化学楼）631b室研究方向：1、疾病分析，如多囊卵巢综合征、痛经、卵巢早衰以及肠炎等；
2、运动及其诱导的因子对疾病的作用机制
南京大学博士，南京大学医学院基础医学教授、博士生导师。江苏省医学分子技术重点实验室pi兼秘书，生命分析化学国家重点实验室pi。曾兼任江苏省动商研究院院长。 教学方面：主讲《组织学与胚胎学》、《人类形体进化与美感》、《生殖生物学》、《组织病理》等8门课程，并承担教学改革项目7项，发表教学改革论文4篇，参编教材1本。 科研方向：疾病分析及其干预措施研究，如多囊卵巢综合征、痛经、卵巢早衰以及肠炎等。主持国家自然科学基金7项，主持其他基金15项，参与973、863、国家科技重大专项等项目若干。发表文章100多篇，其中第一或通讯的sci文章60多篇。
《evidence-based complementary and alternative medicine》的杂志编辑以及多个sci杂志审稿人，国家自然科学基金同行评审专家，江苏省解剖学会常务理事兼副秘书长；江苏省细胞学会生殖分会理事；中国免疫学会终身会员；中国解剖学会会员；江苏省动物学会会员；
yanan zhu, shuo zhang, jiahui sun, tingting wang, qin liu, guanxi wu, yajie qian, weidong yang, yong wang, and wenmei wang. cigarette smoke promotes oral leukoplakia via regulating glutamine metabolism and m2 polarization of macrophage. international journal of oral science, (2021) 13:25. rong wang , daojuan wang , hongwei wang , tingyu wang , yajing weng, yaling zhang, yongzheng luo, yadong lu and yong wang. therapeutic targeting of nrf2signaling by maggot extracts ameliorates inflammation associated intestinal fibrosis in chronic dss-induced colitis, frontiers in immunology, 12(2021):670159. daojuan wang, yajing weng, yaling zhang, rong wang, tingyu wang, jianjun zhou, shanmei shen, hongwei wang, yong wang. exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the nlrp3 inflammasome in mice. science of the total environment 745 (2020) 141049. daojuan wang, tingyu wang, rong wang, xinlin zhang, lei wang, zou xiang, lingjia zhuang, shanmei shen, hongwei wang, qiao gao and yong wang. suppression of p66shc prevents hyjperandrogenism-induced ovarian oxidative stress and fibrosis. journal of transtlational medicine.2020, 18:84 qin liu, maomao zhao, wei chen, kaiyuan xu, fan huang, junxing qu, zhen xu, xiang wang, yong wang, yanan zhua, wenmei wang, mainstream cigarette smoke induces autophagy and promotes apoptosis in oral mucosal epithelial cells. archives of oral biology, 111 (2020) 104646. ya-nan zhu, yi-ting zhang, qin liu, shan-mei shen, xiang zou, yun-xia cao, wen-jun wang, long yi, qian gao2, wei-dong yang1* and yong wang. association analysis between the tag single nucleotide polymorphisms of dennd1a and the risk of polycystic ovary syndrome in chinese han women. bmc medical genetics (2020) 21:14. https: //doi.org/10.1186/s12881-019-0945-1. rong wang, yongzheng luo, yadong lu, daojuan wang, tingyu wang, wenyuan pu, and yong wang. maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of nrf2. oxid med cell longev. 2019 nov 15; 2019: 4703253. doi: 10.1155/2019/4703253. wang r, wang l, luo y, wang d, du r, du j, wang y. maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice. biosci rep. 2018 nov 28;38(6). pii: bsr20181799. wang d, wang w, liang q, he x, xia y, shen s, wang h, gao q, wang y. dhea-induced ovarian hyperfibrosis is mediated by tgf-β signaling pathway.j ovarian res. 2018 jan 10;11(1):6. doi: 10.1186/s13048-017-0375-7. chen xf, wang l, wu yz, song sy, min hy, yang y, he x, liang q, yi l, wang y, gao q. effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidativecapacity and biogenesis in skeletal muscle in diabetic rats. nutr diabetes. 2018 jan 12;8(1):1. doi: 10.1038/s41387-017-0009-6. linghui kong, qien wang, jiewen jin, zou xiang, taoyu chen, shanmei shen, hongwei wang, qian gao, yong wang insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. plos one. 2017 nov 10;12(11):e0188029. deng z, liu x, jin j, xu h, gao q, wang y, zhao j. histone deacetylase inhibitor trichostatin a promotes the apoptosis of osteosarcoma cellsthrough p53 signaling pathway activation. 2016;12(11): 1298-1308. yanjie xia, wenqing wang , lei wang , shanmei shen , yunxia cao , long yi, qian gao and yong wang, hogg1 gene polymorphisms and susceptibility to polycystic ovary syndrome, biomedical reports 4: 421-426, 2016 xiao huang, jiewen jin, shanmei shen, yanjie xia, pei xu, xiang zou, hongwei wang, long yi, yong wang & qian gao (2015): modulation of expression of 17-hydroxylase/17,20 lyase (cyp17) and p450 aromatase (cyp19) by inhibition of mek1 in a human ovarian granulosa-like tumor cell line, gynecological endocrinology, 2016;32(3):201-5. yanjie xia, shanmei shen , xinlin zhang, zhantao deng, zou xiang, hongwei wang, long yi, qian gao and yong wang, epigenetic pattern changes in prenatal female sprague-dawley rats following exposure to androgen, reproduction, fertility and development 2015 mar 31. doi: 10.1071/rd14292. qu j, che y, xu p, xia y, wu x and wang y. the higher response of vascular endothelial growth factor and angiotensin-ii to human chorionic gonadotropin in women with polycystic ovary syndrome. int j fertil steril 2015 8:373-8 chen j, shen s, tan y, xia d, xia y, cao y, wang w, wu x, wang h, yi l, gao q and wang y. the correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. j ovarian res 2015 mar 22;8:11. doi: 10.1186/s 13048- 015- 0139- 1. wang c, gao c, meng k, qiao h and wang y. human adipocytes stimulate invasion of breast cancer mcf-7 cells by secreting igfbp-2. plos one 2015 mar 6;10(3):e0119348. zhang x, zhang c, shen s, xia yj, yi l and wang y. dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. hum reprod 2013 28:3074-85. wang c, gao c, zhuang jl, ding c and wang y. a combined approach identifies three mrnas that are down-regulated by microrna-29b and promote invasion ability in the breast cancer cell line mcf-7. j cancer res clin oncol 2012 dec;138(12):2127-36. zhang c, zhang x, xia y, cao y, wang w, xu p, che y, wu xk, yi l, gao q and wang y. association between polymorphisms of the cyp11a1 gene and polycystic ovary syndrome in chinese women. mol biol rep 2012 39: 8379-8385 xia y, che y, zhang x, zhang c, cao y, wang w, xu p, wu xk, yi l, gao q and wang y. polymorphic cag repeat in the androgen receptor gene in polycystic ovary syndrome patients. mol biol rep 2012 5:1330-1334 zhang xl, zhang cw, xu p, liang fj, che yn, xia yj, cao yx, wu xk, wang wj, yi l, gao q and wang y. snp rs2470152 in cyp19 is correlated to aromatase activity in chinese polycystic ovary syndrome patients. mol biol rep 2012 5:245-249 wang y, wu zw, zhang lf, wu xk, yi l and han xd. effects of ureaplasma urealyticum infection on the male reproductive system in experimental rats. andrologia 2010 42:297-301 wang y, qu j, wu x, hou l and erkkola r. different phenotypes of polycystic ovary syndrome by rotterdam criteria are differently steroidogenic but similarly insulin resistant. fertil steril 2010 93:1362-1365 ke l, che yn, cao yx, wu xk, hu yl, sun hx, liang fj, sun j, yi l and wang y. polymorphisms of the hsd17b6 and hsd17b5 genes in chinese women with polycystic ovary syndrome. j womens health (larchmt) 2010 19:2227-32 xu p, che y, cao y, wu xk, sun h, liang f, sun j, ke l, yi l and wang y. polymorphisms of tcf7l2 and hhex genes in chinese women with polycystic ovary syndrome. j ass reprod gene 2010 27:23-28 qu jw, wang y, wu xk, gao l, hou l, et al. insulin resistance directly contributes to androgenic potential within ovarian theca cells. fertil steril 2009 91:1990-7 jin jl, sun j, ge hj, cao yx, wu xk, liang fj, sun hx, ke l, yi l, wu zw and wang y. association between cyp19 gene snp rs2414096 polymorphism and polycystic ovary syndrome in chinese women. bmc med genet 2009 10:139 liang fj, wu xk, qu jw, ke l, sun j and wang y. response of igf and il-6 to ovarian stimulation in pcos and normal women. syst biol reprod med 2009 55: 227-35. sun j, fan h, che y, cao y, wu x, sun hx, liang f, yi l and wang y. association between ace gene i/d polymorphisms and hyper- androgenism in women with polycystic ovary syndrome (pcos) and controls. bmc med genet 2009 10:64. wang y, wu xk, cao y, yi l and chen j. a microsatellite polymorphism (tttta)n in the promoter of cyp11a gene in chinese women with polycystic ovary syndrome. fertil steril 2006 86:223-226. wang y, wu xk, cao y, yi l, fan h and chen j. polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in chinese women with polycystic ovary syndrome. fertil steril. 2006 may;85(5):1536-40.
主持国家自然科学基金面上项目： 1、基于tlr4/nf-κb/nets通路研究nlrp3介导高雄诱导卵泡发育障碍的分子机制 ，81971346，2020年01月至 2023年 12月 2、发育期高雄激素介导卵巢细胞间去乙酰化酶差异表达在pcos发病中的机制研究, 81771539, 2018-01-01~2021-12-31. 3、p66shc调控pcos卵巢纤维化病理的机理研究, 81471422, 2015-01-01~2018-12-31. 4、pcos雄激素代谢相关基因的遗传（htsnps）与表遗传（dna甲基化）调控机制研究,81170541,2012-01-01~2015-12-31. 5、胰岛素信号系统相关基因多态性与pcos表型的关系探索，30672228,2007.1.1~2009.12.31.
曾获评： “南京大学育教融合奖” “本科生教学优秀”； “学生最喜爱的老师”； “招生工作先进个人”； “优秀博士生导师”； “南京大学魅力导师”； “群众体育先进个人”
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