童智慧博士
副教授
电话：025-80860007邮箱：njzyantol@hotmail.com 地址：南京市中山东路305号研究方向：外科危重症；急性胰腺炎；腹腔感染
金陵医院（东部战区总医院）重症医学科副主任，在外科危重病及重症急性胰腺炎的综合救治方面做了大量突破性的创新工作，主要包括：（1）重症急性胰腺炎早期mods系列防治关键技术的建立；（2）重症急性胰腺炎早期肠内营养技术体系的创建；（3）严重腹腔感染微创引流技术体系的建立。目前主要的研究方向有：（1）重症急性胰腺炎的临床和基础研究；①重症急性胰腺炎早期全身炎症反应和多器官功能障碍的预防和治疗；②高甘油三酯血症性胰腺炎特征性的病理生理改变及治疗；③急性胰腺炎后糖尿病的发生及发展机制研究。（2）严重腹腔感染微创引流体系的优化；（3）危重病患者的营养支持治疗和代谢调理；（4）战创伤患者的无创监测。
全军重症医学专业委员会委员兼秘书 中华医学会重症医学分会青年委员 中国医师协会胰腺病分会急性胰腺炎学组委员 中国医师协会微无创医学专业委员会胰腺专业委员会委员 中国研究型医院学会胰腺病分会急性胰腺炎学组委员 江苏省医学会重症医学分会委员 江苏省医学会胰腺病分会胰腺炎学组委员
gang li, lu ke, zhihui tong, weiqin li, xin ouyang, chunbo chen. is it necessary for all patients to use prokinetic agents to place a trans-pyloric tube? intensive care med,2019 may;45(5):751-752 li g, gao l, zhou j, ye b, zhang j, qu c, ke l, tong z, li w. management of splenic abscess after splenic arterial embolization in severe acute pancreatitis: a 5-year single-center experience. gastroenterol res pract. 2019 jul 1;2019:6069179. ke l, mao w, zhou j, ye b, li g, zhang j, wang p, tong z, windsor j, li w. stent-assisted percutaneous endoscopic necrosectomy for infected pancreatic necrosis: technical report and a pilot study. world j surg. 2019 apr;43(4):1121- 1128. gao l, zhang jz, gao k, zhou j, li g, li bq, ye b, ke l, tong zh, li wq. management of colonic fistulas in patients with infected pancreatic necrosis being treated with a step-up approach. hpb (oxford). 2020 apr 26:s1365-182x(20)30108-8. tu j, zhang j, yang y, xu q, ke l, tong z, li w, li j. comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: a long-term study. exp ther med. 2020 nov;20(5):75 xiaochun xie,jie dong,guotao lu,kun gao,xiaoyao li,wenjian mao,faxi chen,zhihui tong,baiqiang li,weiqin li. increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis. bmc gastroenterol. 2020 jul 13;20(1):222 qu c, gao l, yu xq, wei m, fang gq, he j, cao lx, ke l, tong zh, li wq. machine learning models of acute kidney injury prediction in acute pancreatitis patients. gastroenterol res pract. 2020 sep 29;2020 qu c, zhang h, chen t, zhu y, feng q, guo f, liu z, cao l, yang j, li g, ye b, zhou j, ke l, tong z, windsor j, li w; chinese acute pancreatitis clinical trials group (capctg). early on-demand drainage versus standard management among acute necrotizing pancreatitis patients complicated by persistent organ failure: the protocol for an open-label multi-center randomized controlled trial. pancreatology. 2020 aug 23:s1424-3903(20)30662-1. qu c, yu x, duan z, zhou j, mao w, wei m, cao l, zhang j, zhang h, ke l, tong z, li w. clinical characteristics and management of gastric outlet obstruction in acute pancreatitis. pancreatology. 2021 jan;21(1):64-68. ke l, dong x, chen t, doig gs, li g, ye b, zhou j, xiao x, tong z, li w; chinese acute pancreatitis clinical trials group (capctg). early on-demand drainage or standard management for acute pancreatitis patients with acute necrotic collections and persistent organ failure: a pilot randomized controlled trial. j hepatobiliary pancreat sci. 2021 apr;28(4):387-396. zhang x, ye b, mao w, liu l, li g, zhou j, zhang j, guo j, ke l, tong z, li w. major adverse kidney events within 30 days in patients with acute pancreatitis: a tertiary-center cohort study. hpb (oxford). 2021 jun 7:s1365-182x hao h, liu y, cao j, gao k, lu y, wang w, wang p, lu s, hu l, tong z, li w. genomic new insights into emergence and clinical therapy of multidrug-resistant klebsiella pneumoniae in infected pancreatic necrosis. front microbiol. 2021 jun 25;12:669230. dong x, mao w, ke l, gao l, zhou j, ye b, li g, phillips a, tong z, windsor j, li w, chinese acute pancreatitis clinical trials group capctg. the diagnosis and treatment of local complications of acute necrotizing pancreatitis in china: a national survey. gastroenterol res pract. 2021 jul 10;2021:6611149. zhou j, chen w, liu y, qu c, jiang w, yin j, lin j, mao w, ye b, zhou j, ke l, tong z, liu y, li w. trajectories of lymphocyte counts in the early phase of acute pancreatitis are associated with infected pancreatic necrosis. clin transl gastroenterol. 2021 sep 22;12(9):e00405. lu y, lu g, gao l, zhu q, xue j, zhang j, ma x, ma n, yang q, dong j, gong w, li w, tong z. the proresolving lipid mediator maresin1 alleviates experimental pancreatitis via switching macrophage polarization. mediators inflamm. 2021 mar 9;2021:6680456. cao l, zhou j, chen m, et al. the effect of plasma triglyceride-lowering therapy on the evolution of organ function in early hypertriglyceridemia-induced acute pancreatitis patients with worrisome features (perform study): rationale and design of a multicenter, prospective, observational, cohort study. front med (lausanne). 2021;8:756337. shi x, hu y, pu n, et al. risk factors for fetal death and maternal ap severity in acute pancreatitis in pregnancy. front pediatr. 2021;9:769400. wei m, zhang j, qu c, et al. the involvement of renal capsule is associated with acute kidney injury in patients with acute pancreatitis. front med (lausanne). 2021;8:724184 tang q, gao l, tong z, li w. hyperlipidemia, covid-19 and acute pancreatitis: a tale of three entities. am j med sci. 2022;s0002-9629(22)00132-x. ke l, lin j, doig gs, et al. actively implementing an evidence-based feeding guideline for critically ill patients (need): a multicenter, cluster-randomized, controlled trial. crit care. 2022;26(1):46. qu c, duan z, xiao x, et al. nonthyroidal illness syndrome in acute pancreatitis patients: an 8-year cohort study. bmc gastroenterol. 2022;22(1):40. ke l, zhou j, mao w, et al. immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial. intensive care med. 2022;48(7):899-909.
高堃，童智慧，李维勤. 胰腺坏死组织感染的影像学特征、微创介入方式及时机. 中国实用外科杂志,2019,39(6):575-580. 皋林，童智慧，李维勤. 美国胃肠病协会关于急性胰腺炎胰腺坏死处理临床实践专家共识更新解读. 中国实用外科杂志, 2019,39(12):1257-1264. 高堃，童智慧，李维勤. 胆源性胰腺炎诊治难点思考. 中国实用外科杂志, 2020,40(11):1270-1274. 高堃，瞿诚，童智慧，李维勤. 急性胰腺炎的严重度评估与重症化预测. 中国实用内科杂志, 2021,41(1):1270-1274. 张敬柱，杨洁，李刚，张和，柯路，周晶，叶博，刘玉秀，童智慧，李维勤. 胰腺坏死组织感染并发十二指肠瘘诊治及预后研究. 中国实用外科杂志, 2021,41(3):315-319. 高堃，童智慧，李维勤. 新的治疗模式下胰腺坏死组织感染开腹手术指征和时机的思考. 中国普通外科杂志, 2021,30(9):3-9.
1、2013.1-2015.12 胆道压力的变化在腹腔高压导致mods中的作用及机制探讨，国家自然科学基金青年项目（81200334，经费23万） 2、2017.1-2020.12 高密度脂蛋白通过sr-b1保护急性胰腺炎腺泡细胞损伤的作用及机制研究，国家自然科学基金面上项目（81670588，经费58万） 3、2015.7-2018.6 急性胰腺炎规范化诊疗研究，江苏省社会发展-重点病种规范化诊疗诊疗项目（be2015685，经费400万） 4、2016.7-2019.6 胰腺坏死感染微创治疗技术体系的建立--阶梯式引流新技术，江苏省重点研发计划（社会发展）项目（be2016749，经费400万） 5、2023.1-2026.12 海藻糖通过il-17a减轻重症急性胰腺炎损伤的作用及机制研究，国家自然科学基金面上项目（81670588，经费53万）
1.重症急性胰腺炎救治关键技术的创新与应用，教育部科技进步二等奖，2017年（2/15） 2.重症急性胰腺炎的实验和临床研究，江苏省科技进步一等奖，2008年（3/9） 3.中华医学会“第二届全国普通外科青年医师奖”、“第二届重症医学青年研究奖”、国际胰腺病学会优秀论文三等奖、“黎介寿医学基金奖”、“江苏省青年医学人才”、江苏省第六期“333高层次人才培养工程”培养对象等。
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